The Attenuation of the Virus of Epizootic Hemorrhagic Disease of Deer by Its Serial Passage in the Brains of Newborn Mice

نویسندگان

  • Richard E. Shope
  • Lester G. MacNamara
  • Norma E. Mettler
چکیده

Serial passage through the brains of newborn mice markedly attenuates the New Jersey strain of EHD virus. Deer inoculated with this attenuated virus show no clinical evidence of illness, but do develop virus-neutralizing antibodies in their sera. They also become solidly immune to infection with the regularly fatal unattenuated virus.

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منابع مشابه

The Propagation of the Virus of Epizootic Hemorrhagic Disease of Deer in Newborn Mice and Hela Cells

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عنوان ژورنال:
  • The Journal of Experimental Medicine

دوره 118  شماره 

صفحات  -

تاریخ انتشار 1963